Ginkgo, an ancient native plant that has existed since ancient times, especially in China, Korea, and Japan, has large stems, fan-shaped leaves. Ginkgo is used as part of traditional Chinese medicine and is believed to help alleviate a number of symptoms related to the brain, thought, and circulatory system. In addition, ginkgo seeds can also be used for cooking.
Ginkgo biloba contains two main active ingredients, Flavonoids, and Terpenoids, which have antioxidant properties. It is taken orally and is believed to stimulate the circulatory system, which may improve the functioning of the brain, eyes, ears, and legs. Alleviating the symptoms of Alzheimer’s disease Memory loss, ADHD, headache, dizziness, tinnitus, hearing disorders. In addition, ginkgo seeds contain substances that have an antibacterial and antifungal activity that can cause infection in the body. But there can also be a naturally occurring toxin that can cause seizures or loss of consciousness.
How much evidence or medical evidence is there to confirm the properties, benefits, and safety of eating ginkgo? Ginkgo extract Including extracts from ginkgo leaves that play a role or help in the treatment of these diseases.
Ginkgo biloba treatments that may work
Thoughts and memory
There is some debate about the effectiveness of ginkgo in the development of thinking and memory. But most research suggests that taking ginkgo might slightly improve thinking, memory, and concentration in healthy adults. The intake of 120-240 mg per day appears to be more effective than the large intake, or 600 mg per day. In addition, some studies on taking ginkgo with other herbs or supplements, such as ginseng, may improve thinking and memory better than eating ginkgo alone.
However, taking ginkgo together with ginseng does not improve the thinking or mood of menopausal women. Therefore, further studies are needed to confirm the efficacy of ginkgo. However, taking ginkgo together with ginseng does not improve the thinking or mood of menopausal women. Therefore, further studies are needed to confirm the efficacy of ginkgo.
The a current lack of evidence and conclusions about the effectiveness of ginkgo on neurological symptoms such as autism, depression, ADHD, as well as anxiety disorders. This has led to a review of relevant research on the efficacy of ginkgo biloba on neurological disorders, including generalized anxiety disorder. 82 patients were randomly assigned to take 480 mg of ginkgo leaf extract per day or 240 mg per day.
It was found that patients had a 41% and 31% response to the treatment, respectively, compared to placebo with just 22% of the response and the safety was at a good level. Therefore may be effective in treating anxiety disorders But more research is still needed.
Glaucoma is the leading cause of the loss of retinal ganglion cells and axons, as well as increased eye pressure, which can lead to blindness. Therefore, doubt about the effectiveness of ginkgo on eye pressure. As a result, research has shown that lowering eye pressure is still the accepted treatment for glaucoma. However, ginkgo biloba extract may benefit glaucoma patients and may be used as an alternative treatment for patients with normal-tension glaucoma and high tension glaucoma.
In addition, another study involved 27 glaucoma patients taking 40 milligrams of ginkgo extract three times a day for four weeks, and then taking a break for 8 weeks and took a placebo containing 40 mg of fructose for 4 weeks. The results showed that Ginkgo may improve the visual field of glaucoma. But due to the small number of samples, Further studies are needed to confirm the efficacy of ginkgo biloba.
Symptoms before menstruation
It is one of the chronic conditions that most women in menstruation experience. Which may affect daily use. This makes herbal remedies an alternative that may provide less relief from symptoms and side effects. Therefore, one trial randomly assigned 90 female college students with pre-menstrual symptoms to take 40 mg ginkgo leaf extract or placebo three times per day, starting on the 16th day of the menstrual cycle.
Until the 5th day of the next round. It was found that overall pre-menstrual symptoms were significantly reduced. In the group taking ginkgo leaf extract, the severity of symptoms was lower than that of the placebo group. However, more studies on the active ingredients, efficacy, safety, dosage, and duration of treatment are still needed.
As a side effect from the use of antipsychotic drugs, This causes the patient to have a twisted or repetitive movement disorder of the original muscle, especially in the face. Which free radicals may be involved in the development of this condition, One trial randomly assigned patients to take 240 mg of ginkgo leaf extract per day or a placebo for 12 weeks and found that ginkgo might be effective in treating and alleviating symptoms of the condition. In patients with schizophrenia.
Symptoms are more common and are more common in females than in males and affect daily life. One trial randomly assigned 160 patients with a mean age of 58 years to take 240 mg of ginkgo biloba extract per day or betahistine. (Betahistine) 32 mg daily for 12 weeks. It was found that ginkgo extract was as effective in treating dizziness as betahistine. Which is a drug used to treat dizziness widely today.
Possible ginkgo treatments But there is not enough evidence to support it.
Initial studies were conducted on the use of Ginkgolide B, a type of ginkgo leaf extract, in the prevention of migraine headaches. The drug was discontinued two months prior to the trial and taken 60 mg ginkgo biloba extract, 11 mg coenzyme Q10, and 8.7 mg of vitamin B12 twice daily. 4 months and have the patient record a report of neurological symptoms duration and frequency of symptoms.
Found that GinkgolidesType B substance is effective in reducing the frequency and duration of migraine headaches. The results were evident at the beginning and increased during the second phase of treatment, but because the evidence supporting Ginkgo’s properties for migraine headache was insufficient. Therefore it is necessary to further study.
Macular degeneration in the elderly
It is a disease that affects the retina or retina. This will cause deterioration due to age or in some cases may cause wounds to the retina and affect vision. Which ginkgo is believed to have antioxidant properties and helps slow down the deterioration of the retina. So one trial in France compared the efficacy of ginkgo with a placebo. Patients were randomly assigned to take 80 mg ginkgo leaf extract twice a day or a placebo.
Another trial in Germany randomized patients to take 240 mg of ginkgo leaf extract per day and at 60 mg per day. Both trials were 6 months, although both trials reported positive effects of ginkgo on vision. But the sample is small. Have a short trial period Impact and quality of life are not assessed. This makes it unanswered whether ginkgo is beneficial for macular degeneration patients or not. In addition, the researchers suggest that future studies should increase sample size and trial time for more effective evaluation.
Based on a study by reviewing relevant research on the efficacy of ginkgo biloba on neurodegenerative disorders. Patients with autism were randomly assigned to take ginkgo biloba or placebo. Together with taking drugs Risperidone. Found to be safe Can be used with pediatric patients. Can tolerate side effects well. But no statistically significant difference was found and it seems that the use of ginkgo biloba as an adjunct treatment with risperidone may not be effective.
But there is research from one preliminary observation. Patients with autism took 100 mg of ginkgo biloba extract for 4 weeks, which was found to be beneficial for behavioral disorders. This includes symptoms and suggests that ginkgo may be effective as an adjunct treatment for autism. But because evidence to support Ginkgo’s properties against autism is insufficient. Therefore more studies are needed.
A randomized trial of 106 patients with Acute Idiopathic Sudden Sensorineural Hearing Loss was at least 15 decibels that occurred in less than 10 days. Prior to the trial, 120 mg ginkgo leaf extract was administered twice a day and a 12 mg dose for 8 weeks, it was found that taking ginkgo leaf extract appeared to improve recovery in patients with loss. Loss of hearing Especially those who have eaten in high amounts and have no symptoms of tinnitus. But because the evidence to support ginkgo’s auditory properties is insufficient. Therefore it is necessary to further study.
Some people with ADHD may respond differently to medications. People who respond poorly to the drug may be interested in alternative therapies. Ginkgo biloba is an herb that is presumed to be of therapeutic benefit. A clinical pilot study where ADHD children took ginkgo leaf extract for three to five weeks was able to increase the maximum dose of 240 milligrams per day in patients whose concentration problems had not improved.
Evidence from this study suggests that taking ginkgo biloba extract at a maximum dose of 240 mg per day may be a medically viable alternative for ADHD. But more studies are needed before concluding the efficacy of the treatment.
In addition, another study randomly assigned ADHD patients to take 80-120 mg of ginkgo biloba extract per day. Or taking methylphenidate (Methylphenidate) 20-30 mg daily for 6 weeks. It was found that treatment of ADHD with ginkgo extract was less effective than treatment with methylphenidate. Which further studies are needed.
Ginkgo biloba treatments that may not be effective
There are many other diseases that are believed to be treatable with ginkgo. But there is not enough research to support it, such as high blood pressure, tinnitus, dementia, further studies should be conducted.
Safety of eating ginkgo
Eating ginkgo or ginkgo leaf extract is generally safe if taken in reasonable amounts. But they can also cause side effects such as headache, dizziness, palpitations, nausea, stomach irritation, constipation or diarrhea, and possibly allergic reactions in people who are allergic to ginkgo and also the following precautions for using ginkgo biloba.
Ginkgo biloba extract
- May increase the risk of liver and thyroid cancer. However, there are still only animal trials using large quantities of ginkgo. We have not found enough information to confirm that this risk exists to humans.
- May increase the risk of bruising and bleeding, Where ginkgo affects blood clotting and found that there may be a lot of bleeding after surgery.
- May be unsafe if ginkgo leaf extract is used intravenously.
Seeds or ginkgo leaves
- It may be unsafe to consume more than 10 baked ginkgo seeds per day as it can cause difficulty breathing, weak pulse, seizures, loss of consciousness, and shock.
- Eating fresh ginkgo seeds and leaves may be unsafe. Because fresh ginkgo seeds are toxic They can cause seizures and death.
Including caution in eating ginkgo, especially in the following groups
- People with infertility. Eating ginkgo can affect your pregnancy. You should consult your doctor first if planning a pregnancy.
- People who need to undergo surgery. You should stop taking ginkgo at least 2 weeks before a scheduled surgery, as this may slow blood clotting. Or cause heavy bleeding during or after surgery and ginkgo should not be used in people with bleeding disorders.
- Those who are pregnant or those who are breastfeeding. You should not take ginkgo if you are pregnant or while breastfeeding. Because eating ginkgo may not be safe and it may cause premature labor or heavy bleeding during labor and it is not clear whether eating ginkgo during breastfeeding will harm the mother or the baby.
- People with seizures. You shouldn’t eat ginkgo if you’ve had a seizure. Because it can cause a relapse.
- People with G6PD deficiency should avoid or consume ginkgo with caution. This can cause red blood cell breakdown and severe anemia.
- Infants and children: Eating ginkgo leaf extract is POSSIBLY SAFE if used for a short time.
- Patients with diabetes. May affect the efficacy of the drugs currently in use and should closely control blood sugar levels.
- People who take medications or supplements regularly Including may affect the efficacy of Electroconvulsive Therapy: ECT, because it may cause an adverse reaction. If taking ginkgo with the following drugs Anticoagulants, NSAIDs, Antiplatelet drugs, Anticonvulsants, Antidepressants, Diabetes drugs, Medicines that affect the liver, Herbs such as Garlic, Palmetto, St. John. Wart, etc.